a. Physically painful: "Keen, poignant agonies seemed to shoot from his neck downward" (Ambrose Bierce). b. Keenly distressing to the mind or feelings: poignant anxiety. c. Profoundly moving; touching: a poignant memory. See synonyms at moving.
Dizziness, panic, paranoia, or madness caused by viewing certain artistic or historical artifacts or by trying to see too many such artifacts in too short a time. Also called David's syndrome or tourist's syndrome.